Faculty
Staff
Faculty Openings

Dr. Paul J. Cullen

Assistant Professor
Cooke 341
phone: 716-645-4923
fax: 716-645-2975
email: pjcullen@buffalo.edu
Paul Cullen's Lab

Research Summary

Our lab is interested in signal transduction pathway regulation in the model organism budding yeast. We investigate cell-surface receptors that activate the GTPase Cdc42 and connect to MAP kinase regulatory proteins. We use genetic, biochemical, and genome-wide approaches to investigate questions related to pathway activation, specification and attenuation.

Selected Publications

• Pitoniak, A., Birkaya, B., Dionne H.M., Vadaie, N., and P. J. Cullen (2009) The Signaling Mucins Msb2 and Hkr1 Differentially Regulate the Filamentation MAPK Pathway and Contribute to a Multimodal Response. Molecular Biology of the Cell V20 p3101-3114
  Article

• Birkaya, B. Maddi, A., Joshi, J., Free, S.J., and P.J. Cullen (2009) The Role of the Cell Wall Integrity Pathway and Cdc42-Dependent MAPK Pathway in Cell Wall Remodeling During Filamentous Growth. Eukaryotic Cell V8 p1118-1133
  Article

• Abdullah, U. and P.J. Cullen (2009) The tRNA Modification Complex Elongator Regulates the Cdc42-Dependent MAPK Pathway that Controls Filamentous Growth In Yeast. Eukaryotic Cell V8 p1362-1372
  Article

• Vadaie, N., Dionne, H., Nickerson, S.R., Akajagbor, D.S., Krysan, D.J., and Cullen, P.J. (2008) Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast. J. Cell Biology 181: 1073-1081
  Article

• Cullen, P.J. (2007) Signaling Mucins: The New Kids on the MAPK Block. /*Critical Reviews in Eukaryotic Gene Expression*
  Abstract :: Article

• P.J. Cullen, Xu-Friedman, R., Delrow, J., and G. F. Sprague, Jr. (2006).
  Genome-wide analysis of a protein glycosylation deficiency.
  FEMS Yeast Research
  Abstract :: Article

• Devit, M.J., Cullen, P.J. Branson, M., Sprague, G.F., and Fields, S. (2005).
  A novel genetic screening method based on artificially forced protein interactions. Genome Research 15 (4):560-565.
  Abstract :: Article

• Cullen, P.J., Sabbagh Jr., W., Graham, E., Irick, M. van Olden, E.K., Neal, C., Delrow, J., Bardwell, L., and George F. Sprague, Jr. (2004). A signaling mucin at the head of the Cdc42- and MAPK-filamentous growth pathway in yeast.
  Genes & Development 18:1695-1708
  Abstract :: Article

• Smith, G.R., Given, S.A., Cullen, P.J., and Sprague, G.F. Identification and Characterization of GTPase Activating Proteins (GAPs) for Cdc42 Eukaryotic Cell (2002) V1 p469-480.
  Abstract :: Article

• Cullen, P.J., and Sprague, G.F., Jr. (2002)
  The Glc7p-interacting protein Bud14p attenuates pheromone response, filamentous growth, and polarized growth in
  Saccharomyces cerevisiae.
  Eukaryotic Cell V1:884-894.
  Abstract :: Article

• Cullen, P.J., and Sprague, G.F., Jr. (2002)
  The roles of bud-site-selection proteins in haploid invasive growth in yeast.
  Mol. Biol. Cell 13:2990-3004.
  Abstract :: Article

• Cullen, P.J. and Sprague, G.F. (2000)
  Glucose depletion causes haploid invasive growth in yeast.
  PNAS 97: 13619-13624.
  *See Commentary on this article: Madhani, H.D. (2000) Interplay of intrinsic and extrinsic signals in yeast differentiation. PNAS 97: 13461-13463.
  Abstract :: Article

• Cullen, P.J., Schultz, J., Horecka, J., Stevenson, B., and Jigami, Y., and Sprague, G.F. (2000)
  Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast.
  Genetics 155: 1005-1018.
  Abstract :: Article