Faculty Openings

Dr. Denise Ferkey

Associate Professor
Cooke 353
phone: 645-4929
email: dmferkey@buffalo.edu

Research Summary

Our research is directed towards understanding the regulatory mechanisms that control animal behavior. Using C. elegans sensory behavior (e.g. chemosensation) as a model, we study the regulation of G protein-coupled signal transduction pathways as well as the mechanisms by which the neurotransmitter dopamine modulates signaling and behavior.

Our work is supported by the National Science Foundation and the Ellison Medical Foundation.

Selected Publications

  • Krzyzanowski, M.C., Brueggemann, C., Ezak, M.J., Wood, J.F., Michaels, K.L., Jackson, C.A., Juang, B-T., Collins, K., Yu, M.C., L’Etoile, N.D. and Ferkey, D.M. (2013) The C. elegans cGMP-dependent protein kinase G EGL-4 regulates nociceptive behavioral sensitivity. PLoS Genetics. 9(7): e1003619. doi:10.1371/journal.pgen.1003619.
    Abstract     Article     Supplemental Figure
  • Mann, J.K., Wood, J.F., Stephan, A.F., Tzanakakis, E.S., Ferkey, D.M. and Park, S. (2013) Epitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 Signaling. ACS Chemical Biology. 8(3):608-616.
    Abstract     Article     Supplemental Figures
  • Wood, J.F., Wang, J., Benovic, J.L. and Ferkey, D.M. (2012) Structural domains required for C. elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. Journal of Biological Chemistry. 287(16):12634-12644.
    Abstract     Article    Supplemental Figures
  • Ezak, M.J. and Ferkey, D.M. (2011) A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. PLoS ONE. 6(9): e25047. doi:10.1371/journal.pone.0025047.
    Abstract     Article
  • Huang, H., Delikanli, S., Zeng, H., Ferkey, D.M. and Pralle, A. (2010) Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nature Nanotechnology. 5(8):602-606.
    Abstract     Article    Supplemental Figures
  • Ezak, M.J., Hong, E., Chaparro-Garcia, A. and Ferkey, D.M. (2010) C. elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling. Genetics. 185(1):233-244.
         Article    Supplemental Figures
  • Ezak, M.J. and Ferkey, D.M. (2010) The C. elegans D2-like dopamine receptor DOP-3 decreases sensitivity to the olfactory stimulus 1-octanol. PLoS ONE. 5(3): e9487. doi:10.1371/journal.pone.0009487.
    Abstract     Article     Supplemental Figure
  • Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C. (2007) C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53(1):39-52.
    Abstract     Article
  • Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42(4):581-593.
  • Ferkey, D.M. and Kimelman, D. (2002) Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin. Journal of Biological Chemistry. 277(18):16147-16152.
  • Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) Tcf4 can specifically recognize β-catenin using alternative conformations. Nature Structural Biology. 8(12):1048-1052.
  • Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme. Developmental Biology. 225:471-479.
  • Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification. The Journal of Cell Biology. 148(4):691-701.
  • Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell. 93:1031-1041.
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