Research Summary
Our research is directed towards understanding the regulatory mechanisms that control animal behavior. Using C. elegans sensory behavior (e.g. chemosensation) as a model, we study the regulation of G protein-coupled signal transduction pathways as well as the mechanisms by which the neurotransmitter dopamine modulates signaling and behavior.
Selected Publications
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Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C. (2007) C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53(1):39-52. Abstract Article.
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Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42(4):581-593. Abstract Article
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Ferkey, D.M. and Kimelman, D. (2002) Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin. Journal of Biological Chemistry. 277(18):16147-16152. Article
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Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) Tcf4 can specifically recognize β-catenin using alternative conformations. Nature Structural Biology. 8(12):1048-1052. Article
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Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme. Developmental Biology. 225:471-479. Article
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Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification. The Journal of Cell Biology. 148(4):691-701. Article
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Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell. 93:1031-1041. Article
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