Faculty Openings

Dr. Denise Ferkey

Associate Professor
Cooke 353
phone: 645-4929
email: dmferkey@buffalo.edu

Research Summary

Our research is directed towards understanding the regulatory mechanisms that control animal behavior. Using C. elegans sensory behavior (e.g. chemosensation) as a model, we study the regulation of G protein-coupled signal transduction pathways as well as the mechanisms by which the neurotransmitter dopamine modulates signaling and behavior.

Funding Support:
Ellison Medical Foundation
National Science Foundation
National Institutes of Health

Selected Publications

  • Krzyzanowski, M.C., Brueggemann, C., Ezak, M.J., Wood, J.F., Michaels, K.L., Jackson, C.A., Juang, B-T., Collins, K., Yu, M.C., L’Etoile, N.D. and Ferkey, D.M. (2013) The C. elegans cGMP-dependent protein kinase G EGL-4 regulates nociceptive behavioral sensitivity. PLoS Genetics. 9(7): e1003619. doi:10.1371/journal.pgen.1003619.
    Abstract     Article     Supplemental Figure
  • Mann, J.K., Wood, J.F., Stephan, A.F., Tzanakakis, E.S., Ferkey, D.M. and Park, S. (2013) Epitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 Signaling. ACS Chemical Biology. 8(3):608-616.
    Abstract     Article     Supplemental Figures
  • Wood, J.F., Wang, J., Benovic, J.L. and Ferkey, D.M. (2012) Structural domains required for C. elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. Journal of Biological Chemistry. 287(16):12634-12644.
    Abstract     Article    Supplemental Figures
  • Ezak, M.J. and Ferkey, D.M. (2011) A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. PLoS ONE. 6(9): e25047. doi:10.1371/journal.pone.0025047.
    Abstract     Article
  • Huang, H., Delikanli, S., Zeng, H., Ferkey, D.M. and Pralle, A. (2010) Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nature Nanotechnology. 5(8):602-606.
    Abstract     Article    Supplemental Figures
  • Ezak, M.J., Hong, E., Chaparro-Garcia, A. and Ferkey, D.M. (2010) C. elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling. Genetics. 185(1):233-244.
         Article    Supplemental Figures
  • Ezak, M.J. and Ferkey, D.M. (2010) The C. elegans D2-like dopamine receptor DOP-3 decreases sensitivity to the olfactory stimulus 1-octanol. PLoS ONE. 5(3): e9487. doi:10.1371/journal.pone.0009487.
    Abstract     Article     Supplemental Figure
  • Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C. (2007) C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53(1):39-52.
    Abstract     Article
  • Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42(4):581-593.
  • Ferkey, D.M. and Kimelman, D. (2002) Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin. Journal of Biological Chemistry. 277(18):16147-16152.
  • Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) Tcf4 can specifically recognize β-catenin using alternative conformations. Nature Structural Biology. 8(12):1048-1052.
  • Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme. Developmental Biology. 225:471-479.
  • Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification. The Journal of Cell Biology. 148(4):691-701.
  • Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell. 93:1031-1041.
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