Dr. Denise Ferkey

Ezak, M.J., Hong, E., Chaparro-Garcia, A. and Ferkey, D.M. (2010) C. elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling. Genetics. 185(1):233-244.
Abstract Article Supplemental Figures

Ezak, M.J. and Ferkey, D.M. (2010) The C. elegans D2-like dopamine receptor DOP-3 decreases sensitivity to the olfactory stimulus 1-octanol. PLoS ONE. 5(3): e9487. doi:10.1371/journal.pone.0009487.
Abstract Article Supplemental Figure

Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C. (2007) C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53(1):39-52.
Abstract Article

Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42(4):581-593.
Abstract Article

Ferkey, D.M. and Kimelman, D. (2002) Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin. Journal of Biological Chemistry. 277(18):16147-16152.
Article

Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) Tcf4 can specifically recognize β-catenin using alternative conformations. Nature Structural Biology. 8(12):1048-1052.
Article

Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme. Developmental Biology. 225:471-479.
Article

Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification. The Journal of Cell Biology. 148(4):691-701.
Article

Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell. 93:1031-1041.
Article


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Faculty Staff Faculty Openings			Dr. Denise Ferkey Assistant Professor Cooke 353 phone: 645-4929 email: dmferkey@buffalo.edu
			Research Summary Our research is directed towards understanding the regulatory mechanisms that control animal behavior. Using C. elegans sensory behavior (e.g. chemosensation) as a model, we study the regulation of G protein-coupled signal transduction pathways as well as the mechanisms by which the neurotransmitter dopamine modulates signaling and behavior. Our work is supported by the National Science Foundation and the Ellison Medical Foundation. Selected Publications Wood, J.F., Wang, J., Benovic, J.L. and Ferkey, D.M. (2012) Structural Domains Required for C. elegans G Protein-Coupled Receptor Kinase 2 (GRK-2) Function in vivo. Submitted. Ezak, M.J. and Ferkey, D.M. (2011) A functional nuclear localization sequence in the C. elegans TRPV Channel OCR-2. PLoS ONE. 6(9): e25047. doi:10.1371/journal.pone.0025047. Abstract Article Huang, H., Delikanli, S., Zeng, H., Ferkey, D.M. and Pralle, A. (2010) Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nature Nanotechnology. 5(8):602-606. Abstract Article Supplemental Figures Ezak, M.J., Hong, E., Chaparro-Garcia, A. and Ferkey, D.M. (2010) C. elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling. Genetics. 185(1):233-244. Abstract Article Supplemental Figures Ezak, M.J. and Ferkey, D.M. (2010) The C. elegans D2-like dopamine receptor DOP-3 decreases sensitivity to the olfactory stimulus 1-octanol. PLoS ONE. 5(3): e9487. doi:10.1371/journal.pone.0009487. Abstract Article Supplemental Figure Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C. (2007) C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron. 53(1):39-52. Abstract Article Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42(4):581-593. Abstract Article Ferkey, D.M. and Kimelman, D. (2002) Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin. Journal of Biological Chemistry. 277(18):16147-16152. Article Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) Tcf4 can specifically recognize β-catenin using alternative conformations. Nature Structural Biology. 8(12):1048-1052. Article Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme. Developmental Biology. 225:471-479. Article Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification. The Journal of Cell Biology. 148(4):691-701. Article Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell. 93:1031-1041. Article
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Dr. Denise Ferkey

Research Summary

Selected Publications