Research Summary
RNA-protein interactions are crucially important in many biological processes. My research involves investigating RNA-protein interactions involved in regulating gene expression. The model system we are studying is the tryptophan biosynthetic (trp) operon from Bacillus subtilis and several other related Bacilli.
Selected Publications
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Chen, Y., and Gollnick, P. (2008) Alanine Scanning Mutagenesis of Anti-TRAP (AT) Reveals Residues Involved in Binding to TRAP. J. Mol. Biol. 377, 1529-1543.
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Barbolina, M. V., Kristoforov R., Manfredo, A., and Gollnick, P. (2007) The Rate of TRAP Binding to RNA is Crucial for Transcription Attenuation Control of the B. subtilis trp Operon J. Mol. Biol. 370, 925-938.
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Fairman, M.E., Wang, W., Maroney, P.A., GOLLNICK, P., Luhrmann, R., Nilsen, T.W., and Jankowsky, E. (2004) Active Remodeling of Ribonucleoprotein Complexes by a DexH/D ATPase Independent of Duplex Unwinding. Science 304, 730-734
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Snyder, D., Lary, J., Chen, Y., GOLLNICK, P., and Cole, J.L. (2004) Interaction of the Trp RNA-binding Attenuation Protein J. Mol. Biol. 338, 669-682.
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Hopcroft, N.H., Manfredo, A., Wendt, A.L., Brzozowski, A.M., GOLLNICK, P., and Antson, A.A. (2004) The Interaction of RNA with TRAP: Role of Triplet Repeats and Spacer Nucleotides. J. Mol. Biol. 338, 43-53.
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Li, P.T., and GOLLNICK, P. (2004) Characterization of a trp RNA-binding Attenuation Protein (TRAP) Mutant with Tryptophan Independent RNA Binding Activity. J. Mol. Biol. 335, 707-722.
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Szigeti, R., Milescu, M. and GOLLNICK, P. (2004) Regulation of the Tryptophan Biosynthetic Genes in Bacillus halodurans: Common Elements, Different Strategies as Compared to Bacillus subtillus. J. Bacteriology 186, 818-828.
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