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Dr. Randall D. Shortridge

Associate Professor
Cooke 109
phone: 716-645-4920
fax: 716-645-2975
email: rds@buffalo.edu
website: www.acsu.buffalo.edu/~rds/

Office hours: Mondays 1PM to 3PM or by appointment

Research Summary

Function of the nervous system is being studied using mutants in Drosophila that exhibit paralysis when placed at 38o C. Major effort is being made to study a temperature-sensitive paralytic mutant that carries a mitochondrial defect. This particular mutant exhibits reduced lifespan, motor deficiency, and progressive neurodeneration, all of which are hallmarks of mitochondrial encephalopathies in humans.

Selected Publications

• Liu, W., Gnanasambandam, R., Benjamin, J., Kaur, G., Getman, P.B., Siegel, A.J., Shortridge, R.D. and Singh, S. (2007) Mutations in cytochrome c oxidase subunit Via cause neurodegeneration and motor dysfunction in Drosophila. Genetics, 176, 937-946.

• Kim, S., Chen D-M, Zavarella, K., Fourtner, C.F., Stark, W.S. and Shortridge, R.D. (2003) Substitution of a non-retinal phospholipase C in Drosophila phototransduction. Insect Mol. Biol., 12, 147-153.

• Shim, K, Zavarella, K.M., Thomas, C.F., Shortridge, R.D. and Stark, W.S. (2001) Evidence for indirect control of phospholipase C (PLC-beta) by retinoids in Drosophila phototransduction, Molecular Vision, 7, 216-221.
  http://www.molvis.org/molvis/v7/a30/

• Van Huizen, R., Miller, K., Chen, D.-M., Li, Y., Lai, Z.-C., Raab, R.W., Stark, W.S., Shortridge, R.D. and Li, M. (1998) Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling. EMBO Journal, 17, 2285-2297.
  http://www.emboj.org/cgi/content/full/17/8/2285

• McKay, R.R., Chen, D.-M., Miller, K., Kim, S., Stark, W.S. and Shortridge, R.D. (1995) Phospholipase C rescues visual defect of norpA mutant of Drosophila melanogaster, J. Biol. Chem., 270, 13271-13276.
  http://www.jbc.org/cgi/content/full/270/22/13271