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Dr. Matthew A. Xu-Friedman

Assistant Professor
Hochstetter 661
phone: (716) 645-4992
fax: (716) 645-2975
email: mx@buffalo.edu
Further research info

Research Summary

The Xu-Friedman lab studies the mechanisms and functions of synaptic plasticity, focussing on auditory nerve synapses in the cochlear nucleus as a model system. The lab investigates both activity- and neuromodulator-dependent plasticities, using electrophysiology and calcium imaging in brain slices. In addition, the functional effects of plasticity are being studied in mice by assessing their ability to localize and analyze sounds.

Research Tools
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Selected Publications
(For a Partial List of Dr. Xu-Friedman's Publications click here)

• Radziwon KE, Stolzberg D, Salvi R, Xu-Friedman MA, and Dent ML (in press) Mouse audiograms using the psychophysical method of constant stimuli. J Comp Physiol A.

• Pliss L, Yang H, and Xu-Friedman MA (in press) Context-dependent effects of NMDA receptors on precise timing information at the endbulb of Held of the cochlear nucleus. J Neurophysiol.

• Yang H and Xu-Friedman MA (2009) Impact of synaptic depression on spike timing at the endbulb of Held. J Neurophysiol. 102: 1699-1710.

• Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina AV, Neef A, Wolf F, Brose N, Xu-Friedman MA, and Moser T (2009) Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse. J Neurosci. 29: 7991-8004.

• Yang H and Xu-Friedman MA (2008) Relative roles of different mechanisms of depression at the mouse endbulb of Held. J Neurophysiol 99, 2510-2521.