Denise Ferkey Assistant Professor Ph.D. 2002 University of Washington Postdoctoral work 2002-2006 Harvard Medical School and Massachusetts General Hospital Cancer Center (American Cancer Society and MGH Fund for Medical Discovery Fellow) Assistant Professor, University at Buffalo. 2006

Address Information

Dr. Denise Ferkey
Department of Biological Sciences
353 Cooke Hall
State University of New York at Buffalo
Buffalo, NY 14260

(716) 645-2363 ext: 234

To send e-mail: dmferkey@buffalo.edu

RESEARCH SUMMARY

Our research is directed towards understanding the regulatory mechanisms that control animal behavior. Using C. elegans sensory behavior (e.g. chemosensation) as a model, we study the regulation of G protein-coupled signal transduction pathways as well as the mechanisms by which the neurotransmitter dopamine modulates signaling and behavior.

SELECTED PUBLICATIONS

• Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C.(2007) "C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli".
  Neuron. 53(1):39-52.Abstract

• Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) "G protein-coupled receptor kinase function is essential for chemosensation in C. elegans."
  Neuron. 42(4):581-593. Abstract   Article

• Ferkey, D.M. and Kimelman, D. (2002) "Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin."
  Journal of Biological Chemistry. 277(18):16147-16152. Article

• Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) "Tcf4 can specifically recognize β-catenin using alternative conformations."
  Nature Structural Biology. 8(12):1048-1052 Article

• Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme.
  Developmental Biology. 225:471-479. Article

• Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) "Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification."
  The Journal of Cell Biology. 148(4):691-701. Article

• Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis."
  Cell. 93:1031-1041. Article