Dr. Denise Ferkey
Department of Biological Sciences
353 Cooke Hall
State University of New York at Buffalo
Buffalo, NY 14260
(716) 645-2363 ext: 234
To send e-mail: email@example.com
Our research is directed towards understanding the regulatory mechanisms that control animal behavior. Using C. elegans sensory behavior (e.g. chemosensation) as a model, we study the regulation of G protein-coupled signal transduction pathways as well as the mechanisms by which the neurotransmitter dopamine modulates signaling and behavior.
Ferkey, D.M., Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R. and Hart, A.C.(2007) "C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli".
Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., and Hart, A.C. (2004) "G protein-coupled receptor kinase function is essential for chemosensation in C. elegans."
Neuron. 42(4):581-593. Abstract Article
Ferkey, D.M. and Kimelman, D. (2002) "Glycogen synthase kinase-3β mutagenesis reveals a common binding domain for GBP and Axin."
Journal of Biological Chemistry. 277(18):16147-16152. Article
Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001) "Tcf4 can specifically recognize β-catenin using alternative conformations."
Nature Structural Biology. 8(12):1048-1052 Article
Ferkey, D.M. and Kimelman, D. (2000) GSK-3: New thoughts on an old enzyme.
Developmental Biology. 225:471-479. Article
Farr III, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C. and Kimelman, D. (2000) "Interaction among GSK-3, GBP, Axin, and APC in Xenopus axis specification."
The Journal of Cell Biology. 148(4):691-701. Article
Yost, C., Farr III, G.H., Pierce, S.B., Ferkey, D.M., Chen, M.M., and Kimelman, D. (1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis."
Cell. 93:1031-1041. Article