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loretzDr. Christopher A. Loretz

Associate Professor
Office: 647 Hochstetter Hall
Office Hours: Mon, Wed, Fri: 9:00 – 10:00am Tue, Thu: 8:30 – 9:30am
Tel: 716-645-4985
E-mail: loretz@buffalo.edu

Ph.D. University of California, Los Angeles
Postdoctoral Research at University of California, Berkeley

Research Summary

Current research centers on the physiology and evolutionary biology of salt and water balance in aquatic vertebrates. Specifically, laboratory projects explore the molecular physiology and evolution of the extracellular calcium-sensing receptor, endocrine mechanisms mediating adaptive changes in drinking and alimentary tract function, and the biophysics of epithelial ion transport in the fishes.

Selected Publications

  • Herberger, A.L., and Loretz, C.A. (2013). Morpholino oligonucleotide knockdown of the extracellular calcium-sensing receptor impairs early skeletal development in zebrafish. Comp. Biochem. Physiol. A: Molec. Integr. Physiol. 166: 470-481.[http://dx.doi.org/10.1016/j.cbpa.2013.07.027]
  • Herberger, A.L., and Loretz, C.A. (2013). Vertebrate extracellular calcium-sensing receptor evolution: selection in relation to life history and habitat. Comp. Biochem. Physiol. D: Genom. Proteom. 8: 86-94.[http://dx.doi.org/10.1016/j.cbd.2012.12.004]
  • Loretz, C.A., Pollina, C., Herberger, A.L., Hyodo, S., and Takei, Y. (2012)Skeletal tissues in Mozambique tilapia (Oreochromis mossambicus) express the extracellular calcium-sensing receptor.Comp. Biochem. Physiol. A: Molec. Integr. Physiol. 163: 311-318[http://dx.doi.org/10.1016/j.cbpa.2012.07.015]
  • Herberger, A., and Loretz, C.A. (2011)Examining phylogenetic history of the extracellular calcium-sensing receptor: a key sensor in calcium homeostatic systems.Front. Endocrin. Conference Abstract: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology [http://dx.doi.org/10.3389/conf.fendo.2011.04.00025]
  • Takei, Y., and C.A. Loretz (2010)The gastrointestinal tract as an endocrine/neuroendocrine/paracrine organ: organization, chemical messengers and physiological targets.In: Fish Physiology, Volume 30, The Multifunctional Gut of Fish (M. Grosell, A.P. Farrell, and C.J. Brauner, Editors), Academic Press, San Diego, 2010, pp. 261-317.[ISBN 0-1237-4982-4]
  • Loretz, C.A., Pollina, C., Hyodo, S., and Takei, Y. (2009)Extracellular calcium-sensing receptor distribution in osmoregulatory and endocrine tissues of the tilapia.Gen. Comp. Endocrinol. 161: 216-228.[http://dx.doi.org/10.1016/j.ygcen.2008.12.020]
  • Takei, Y., and Loretz, C.A. (2006)Chapter 8: Endocrinology.In: The Physiology of Fishes, 3rd Edition (D.H. Evans and J.B. Claiborne, Editors), CRC Press, Boca Raton, pp. 271-318.[ISBN 0-8493-2022-4]
  • Loretz, C.A., Pollina, C., Hyodo, S., Takei, Y., Chang, W., and Shoback, D. (2004)cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated carboxyterminal tail from the Mozambique tilapia (Oreochromis mossambicus).J. Biol. Chem. 279: 53288-53297.[http://www.jbc.org/cgi/content/full/279/51/53288]
  • Loretz, C.A. (Editor) (2002)Looking Beyond the Borders: A Project Directors Handbook of Best Practices for International Research Experiences for Undergraduates, 102 pp.[http://www.nsf.gov/pubs/2006/nsf06204/]
  • Loretz, C.A., Pollina, C., Kaiya, H., Sakaguchi, H., and Takei, Y. (1997)Local synthesis of natriuretic peptides in the eel intestine.Biochem. Biophys. Res. Comm. 238: 817-822.[http://dx.doi.org/10.1006/bbrc.1997.7369]
  • Links to GenBank Data:

Elephantfish (Callorhinchus milii; elephant shark, ghost shark) extracellular calcium-sensing receptor mRNA (GenBank Accession Number GU827711)

http://www.ncbi.nlm.nih.gov/nuccore/GU827711.1

Mozambique tilapia (Oreochromis mossambicus) extracellular calcium-sensing receptor mRNA (GenBank Accession Number AY541693)

http://www.ncbi.nlm.nih.gov/nuccore/AY541693.1