Dr. Randall D. Shortridge
Function of the nervous system is being studied using mutants in Drosophila that exhibit paralysis when placed at 38o C. Major effort is being made to study a temperature-sensitive paralytic mutant that carries a mitochondrial defect. This particular mutant exhibits reduced lifespan, motor deficiency, and progressive neurodeneration, all of which are hallmarks of mitochondrial encephalopathies in humans.
Liu, W., Gnanasambandam, R., Benjamin, J., Kaur, G., Getman, P.B., Siegel, A.J., Shortridge, R.D. and Singh, S. (2007) Mutations in cytochrome c oxidase subunit Via cause neurodegeneration and motor dysfunction in Drosophila. Genetics, 176, 937-946.
Kim, S., Chen D-M, Zavarella, K., Fourtner, C.F., Stark, W.S. and Shortridge, R.D. (2003) Substitution of a non-retinal phospholipase C in Drosophila phototransduction. Insect Mol. Biol., 12, 147-153.
Shim, K, Zavarella, K.M., Thomas, C.F., Shortridge, R.D. and Stark, W.S. (2001) Evidence for indirect control of phospholipase C (PLC-beta) by retinoids in Drosophila phototransduction, Molecular Vision, 7, 216-221.
Van Huizen, R., Miller, K., Chen, D.-M., Li, Y., Lai, Z.-C., Raab, R.W., Stark, W.S., Shortridge, R.D. and Li, M. (1998) Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling. EMBO Journal, 17, 2285-2297.
McKay, R.R., Chen, D.-M., Miller, K., Kim, S., Stark, W.S. and Shortridge, R.D. (1995) Phospholipase C rescues visual defect of norpA mutant of Drosophila melanogaster, J. Biol. Chem., 270, 13271-13276.